Gene Regulation
Both Affymetrix and Illumina offer solutions for studies of gene regulation.
The Affymetrix platform provide tiling arrays for a number of species. Tiling arrays can be used for either chIP-on-chip or transcript mapping experiments.
Affymetrix chIP-on-chip
Chromatin immunoprecipitation coupled with Affymetrix high-density tiling arrays (ChIP-on-chip) is a powerful technique for identifying transcription factor binding sites, sites of histone modification, DNA methylation and other regulatory elements.
Whole-genome coverage is available in seven-array sets for human and mouse, and single-array designs for Arabidopsis, Drosophila, Caenorhabditis elegans, Saccharomyces cerevisiae and Schizosaccharomyces pombe—detect more, with fewer arrays. Single-array designs are available for chromosome 21/22, ENCODE regions and human and mouse promoter regions.
Affymetrix Transcript Mapping
Transcript mapping with GeneChip® Tiling Arrays enables you to interrogate genomes at regular intervals, including both annotated and unannotated regions. With their unbiased approach to genome interrogation, GeneChip Tiling Arrays are an important tool in discovering novel transcripts and building newer, more up-to-date annotations.
Illumina Methylation Analysis
Methylation profiling with BeadArray technology allows researchers to analyze the effects of aberrant methylation (either hyper- or hypomethylation) for a variety of applications.
Illumina has developed a robust methylation profiling platform that provides quantitative methylation measurement at the single-CpG-site level, providing the highest resolution for understanding epigenetic changes.
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